Background: Congenital hemangiomas are benign abnormal proliferation of blood vessels. Noninvoluting\r\ncongenital hemangiomas are a rare variant which persist, and may become bigger. Hemangiomas are known to be\r\nassociated with thrombocytopenia, microangiopathic hemolytic anemia and Kasabach-Merritt phenomenon.\r\nKasabach-Merritt phenomenon is characterized by consumptive coagulopathy with microangiopathic haemolyic\r\nanemia and thrombocytopenia. Platelet sequestration in the hemangioma or increased destruction which may\r\neither be immune or non immune are also further contributors to thrombocytopenia.\r\nCase presentation: A 45 year old female with a non involuting hemangioma and baseline thrombocytopenia was\r\nobserved to develop repeated episodes of transient severe thrombocytopenia associated with a variety of infectious\r\nconditions. Laboratory investigations suggested a peripheral mechanism. Platelet counts always returned to\r\nbaseline levels on resolution of the precipitating infection.\r\nConclusion: The authors report this phenomenon as the first reported case of baseline thrombocytopenia\r\ncomplicated by recurrent episodes of transient severe thrombocytopenia following infections associated with a non\r\ninvoluting congenital hemangioma. The observations made in this patient were unique and hitherto unreported in\r\nmedical literature. Both peripheral sequestration and destructive consumption were considered likely. Consumptive\r\nmechanisms were likely to encompass either or both immune and non immune causes. Further studies are needed\r\nto establish the precise pathogenesis.
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